SCNM1, a putative RNA splicing factor that modifies disease severity in mice

SCNM1, a putative RNA splicing factor that modifies disease severity in mice.

Science (New York, N.Y.), Vol. 301, No. 5635. (15 August 2003), pp. 967-969, doi:10.1126/science.1086187

by David A. Buchner, Michelle Trudeau, Miriam H. Meisler

I use this paper in my graduate genetics course.  It describes the use of inbred strains to map and molecularly identify genes and illustrates a case of strain-specific phenotypes and genetic interactions.  It simultaneously illustrates the power of working with inbred strains and the caveat that phentypes can be strain-specific.