A DNA integrity network in the yeast Saccharomyces cerevisiae

A DNA integrity network in the yeast Saccharomyces cerevisiae.

Cell, Vol. 124, No. 5. (10 March 2006), pp. 1069-1081, doi:10.1016/j.cell.2005.12.036

by Xuewen Pan, Ping Ye, Daniel S. Yuan, Xiaoling Wang, Joel S. Bader, Jef D. Boeke

I use this paper in my graduate genetics course.  It describes a global screen for synthetic defects involving DNA integrity, which reveals a network of 16 functional modules.  The paper illustrates screens based on genetic interactions (in this case, synthetic lethality or fitness defects) and the systems biology used to evaluate the results of such a screen.  It also illustrates the use of Saccharomyces cerevisiae as a model system.