A whole-genome RNAi Screen for C. elegans miRNA pathway genes

A whole-genome RNAi Screen for C. elegans miRNA pathway genes.

Current biology : CB, Vol. 17, No. 23. (4 December 2007), pp. 2013-2022, doi:10.1016/j.cub.2007.10.058

by Devin H. Parry, Jinling Xu, Gary Ruvkun

I use this paper in my graduate genetics course. It describes a whole-genome screen of C. elegans using RNA interference, provides an example of whole-genome parallel reverse genetic screens, and illustrates both the microRNA biosynthesis pathway and a bit of C. elegans biology.