Competition between ADAR and RNAi pathways for an extensive class of RNA targets

Competition between ADAR and RNAi pathways for an extensive class of RNA targets.

  

Nature structural & molecular biology, Vol. 18, No. 10. (11 October 2011), pp. 1094-1101, doi:10.1038/nsmb.2129

by Diane Wu, Ayelet T. Lamm, Andrew Z. Fire

This paper is recommended by Antony Jose (University of Maryland), who writes:

This work is a particularly elegant illustration of the powerful combination of computational methods with biochemical isolation of RNA from different genetic backgrounds. The discovery of numerous sites genome-wide where the transcribed RNA is edited by ADAR is noteworthy.

A whole-genome RNAi Screen for C. elegans miRNA pathway genes

A whole-genome RNAi Screen for C. elegans miRNA pathway genes.

Current biology : CB, Vol. 17, No. 23. (4 December 2007), pp. 2013-2022, doi:10.1016/j.cub.2007.10.058

by Devin H. Parry, Jinling Xu, Gary Ruvkun

I use this paper in my graduate genetics course. It describes a whole-genome screen of C. elegans using RNA interference, provides an example of whole-genome parallel reverse genetic screens, and illustrates both the microRNA biosynthesis pathway and a bit of C. elegans biology.