Genetics, Vol. 77, No. 1. (1 May 1974), pp. 71-94
by S. Brenner
This paper is recommended by Marty Chalfie (Columbia University), who writes:
The Brenner paper is a classic; when does someone have an opportunity to outline the genetics of an entire organism. It is also a terrific paper to go over basis genetic ideas. nearly all the variation affecting gene expression resides.his
Because it's brief, I'm going to quote the entire abstract from this classic:
Methods are described for the isolation, complementation and mapping of mutants of Caenorhabditis elegans, a small free-living nematode worm. About 300 EMS-induced mutants affecting behavior and morphology have been characterized and about one hundred genes have been defined. Mutations in 77 of these alter the movement of the animal. Estimates of the induced mutation frequency of both the visible mutants and X chromosome lethals suggests that, just as in Drosophila, the genetic units in C. elegans are large.
Because it's brief, I'm going to quote the entire abstract from this classic:
Methods are described for the isolation, complementation and mapping of mutants of Caenorhabditis elegans, a small free-living nematode worm. About 300 EMS-induced mutants affecting behavior and morphology have been characterized and about one hundred genes have been defined. Mutations in 77 of these alter the movement of the animal. Estimates of the induced mutation frequency of both the visible mutants and X chromosome lethals suggests that, just as in Drosophila, the genetic units in C. elegans are large.
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