Genome sequence, comparative analysis and haplotype structure of the domestic dog

Genome sequence, comparative analysis and haplotype structure of the domestic dog.

Nature, Vol. 438, No. 7069. (8 December 2005), pp. 803-819, doi:10.1038/nature04338

by Kerstin Lindblad-Toh, Claire M. Wade, Tarjei S. Mikkelsen, et al.

I use this paper in my graduate genetics course because it is the third complete mammalian genome. Being the third genome allowed the first application of a range of comparative methods, revealing several aspects of mammalian genome structure for the first time.  The paper illustrates the methods of comparative genomics, and the application of population genetics to genomics and vice versa.